Product Information
C14340  VX 680(MK 0457,Tozasertib)
Synonyms:Tozasertib,MK 0457
CAS No.:639089-54-6
Molecular Formula:C23H28N8OS
Molecular Weight:464.59
Solubility:Soluble in DMSO;
Appearance:White or pale yellow powder
Storage: -20°C
Chemical Name:N-[4-[4-(4-Methylpiperazin-1-yl)-6-(3-methyl-1H-pyrazol-5-ylamino)pyrimidin-2-sulfanyl]phenyl]- cyclopropanecarboxamide
VX 680(MK 0457,Tozasertib)    Introduction:

Biological Activity:

Potent inhibitor of aurora kinases with Ki values to be 0.6, 18 and 4.6 nM for auraro A, B and C isotypes respectively; inhibiting also ABL (Ki=30 nM) and FLT3 (Ki=30 nM) kinases.   

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