Product Information
C13511  CYC-116(CYC116)
CAS No.:1059105-22-4
Molecular Formula:C18H20N6OS
Molecular Weight:368.46
Solubility:Soluble in DMSO
Appearance:Yellowish to yellow powder
Storage:at -20℃ 2 years
Chemical Name:5-[2,5-Dihydro-2-[[4-(4-morpholinyl)phenyl]imino]-4-pyrimidinyl]-4-methyl-2-thiazolamine
CYC-116(CYC116)    Introduction:
Chemical name:5-[2,5-Dihydro-2-[[4-(4-morpholinyl)phenyl]imino]-4-pyrimidinyl]-4-methyl-2-thiazolamine
Biological Activity:

CYC116 (CYC-116)is an oral small molecule Aurora kinase/VEGFR2 inhibitor with antineoplastic activity. It  inhibits Aurora kinases A and B and VEGFR2, resulting in disruption of the cell cycle, rapid cell death, and the inhibition of angiogenesis.
CYC116(CYC-116) has a unique target profile involving both cell cycle and angiogenesis inhibition mechanisms. In preclinical studies, it demonstrated antitumor activity in both solid tumors and hematological cancers.

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