Product Information
C13842  LY294002
Synonyms:LY 294002
CAS No.:154447-36-6
Molecular Formula:C19H17NO3
Molecular Weight:307.34
Solubility:Soluble in DMSO
Appearance:Off-white solid
Purity:>99%
Pakage:100mg,500mg,1g,2g,5g
Storage:-20C 2 years
LY294002   Introduction:

LY 294002 has been shown to be a potent inhibitor of PI 3-kinase activity, acting as a competitive inhibitor for ATP binding site of the enzyme. LY 294002 inhibits cell proliferation of choroidal melanoma OCM-1 cells, the IC50 observed was about 10 µM, a concentration higher than, but compatible with, the one (1.4 µM) reported for in vitro inhibition of PI 3-kinase activity.LY 294002 is also an inhibitor of casein kinase II. Application of LY 294002 causes a substantial acceleration of MEPP frequency (150 µM) at the frog neuromuscular junction, through a mechanism that is independent of intraterminal calcium. LY 294002 causes the release of MEPPs through a perturbation of synaptotagmin function.


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