Product Information
C14041  AP24534(Ponatinib)
Synonyms:Ponatinib
CAS No.:943319-70-8
Molecular Formula:C29H27F3N6O
Molecular Weight:532.56
Solubility:Soluble to 100 mM in DMSO and to 50 mM in ethanol
Appearance:White powder
Purity:>99%
Pakage:1g,2g,5g
Storage:Store at -20°C
AP24534(Ponatinib)    Introduction:

Alternative Name: Ponatinib

Chemical Name: 3-(2-Imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N-[4-[(4-methyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl]-benzamide

Biological Activity

 


Potent multi-kinase and pan-BCR-ABL inhibitor. Displays potent activity against cell lines expressing native BCR-ABL or BCR-ABLT3151 (IC50 values are 0.37 and 2.0 nM respectively); also inhibits other ABL kinase domain mutants at nanomolar potencies. Exhibits inhibitory activity against PDGFRα, c-Src and c-Kit (IC50 values are 1.1, 5.4 and 12.5 nM respectively); potently inhibits FGFR and VEGFR family kinases. Orally active.

 


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