Product Information
C13542  DCC-2036
Synonyms:DCC-2036
CAS No.:1020172-07-9
Molecular Formula:C30H28FN7O3
Molecular Weight:553.59
Solubility:Unknown
Appearance:
Purity:>99%
Pakage:500mg,1g,2g
Storage:at -20℃ 2 years
DCC-2036   Introduction:
Biological Activity:
DCC-2036 is an ABL switch control inhibitor with IC50 of 0.8 and 2 nM for u-ABL1native and p-ABL1native, respectively. DCC-2036 strongly prevents both unphosphorylated and phosphorylated ABL1 by inducing a type II inactive conformation, and retains efficacy against the majority of clinically relevant CML-resistance mutants, including T315I. DCC-2036 suppresses BCR-ABL1(T315I)-expressing cell lines, prolongs survival in mouse models of T315I mutant CML and B-lymphoblastic leukemia, and inhibits primary patient leukemia cells expressing T315I in vitro and in vivo, supporting its clinical development in TKI-resistant Ph(+) leukemia. In addition, DCC-2036 also inhibits other kinases with IC50 of 2,4,6,34,29 and 38 nM for Flt3, KDR, Tie2, Src, LYN and FGR kinases, respectively.

Related Article:
Related Products:
   Copyright© 2003-2018  Chembest Research Laboratories Limited All rights reserved. 沪ICP备11035973号
    Tel :+86-21-20908456    Fax:+86-21-58180499-808    Address:No.3377 Kangxin Road, Pudong New District,Shanghai,China    PostCode:201318