Product Information
C13690  FTY720(Fingolimod HCL)
Synonyms:Fingolimod HCL, Gilenia
CAS No.:162359-56-0
Molecular Formula: C19H33NO2.HCl
Molecular Weight:343.9
Solubility:Soluble in DMSO at 100 mg/mL; soluble in ethanol at 100 mg/mL; very poorly soluble in water.
Appearance:White to off-white crystalline powder
Purity:>99%
Pakage:500mg,1g
Storage:
FTY720(Fingolimod HCL)   Introduction:
Chemical Name: 2-Amino-2-[2-(4-octylphenyl)ethyl]-1,3-propanediol HCl
FTY720(Fingolimod) is a potent sphingosine-1-phosphate (S1P) receptors agonist with IC50 of 0.137, 10.98 nM for (S)- and (R)- FTY720-phosphate, respectively and reverses the effects of BCR-ABL kinase. It is a novel immunomodulating agent and can sequester lymphocytes in lymph nodes, preventing them from moving to the central nervous system for auto-immune responses in multiple sclerosis and was originally proposed as a anti-rejection medication indicated post-transplantation. It can be phosphorylated by sphingosine kinase and prevents disease in a mouse model of many leukemias caused by BCR-ABL. It does not directly target the BCR-ABL kinase, but instead activates phosphatase 2A (PP2A) which is a tumor suppressor that is inactivated by BCR-ABL.
FTY720(Fingolimod) also mediated antitumor effects in hepatocellular carcinoma (HCC) cells by activating PKC . The three HCC cell lines examined, Hep3B, Huh7, and PLC5, exhibited differential susceptibility to FTY720-mediated suppression of cell viability, with IC50 values of 4.5, 6.3, and 11 μM, respectively.


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