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C14338  Vorinostat (SAHA)
Synonyms:Suberoylanilide hydroxamic acid (SAHA);Suberanilohydroxamic acid; N-Hyrdroxy-N'-phenyloctanediamide;Zolinza, MK-0683
CAS No.:149647-78-9
Molecular Formula:C14H20N2O3
Molecular Weight:264.3
Solubility:Soluble in DMSO and Methanol
Appearance:White to off-white crysta
Vorinostat (SAHA)    Introduction:
Suberoylanilide Hydroxamic Acid (SAHA) is a potent histone deacetylase (HDAC) inhibitor that has been shown to inhibit proliferation, and cause cell cycle arrest at G1. Experiments suggest that SAHA also causes morphological changes, such as enlargement and flattening of the cytoplasm, resulting in growth inhibition. Treatment of cells with SAHA also decreases the expression of anti-apoptosis proteins Bcl-xL and survivin.

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