Product Information
C13850  Varespladib(LY315920,LY-333013)
Synonyms:LY-315920, LY-333013
CAS No.:172732-68-2
Molecular Formula:C21H20N2O5
Molecular Weight:380.40
Solubility:Soluble in DMSO
Appearance:White powder
Storage:at -20℃ 2 years
Varespladib(LY315920,LY-333013)   Introduction:
Chemical Name:  [[3-(Aminooxoacetyl)-2-ethyl-1-(phenylmethyl)-1H-indol-4-yl]oxy]acetic acid

Varespladib is a selective inhibitor of human, group IIA, nonpancreatic secretory PLA2 (sPLA2). In a chromogenic isolated enzyme assay, Varespladib inhibited sPLA2 activity with an IC50 of 9 6 ±1 nM or 7.3 *10-6 mole fraction, which approached the stiochiometric limit of this assay.Varespladib was 40-fold less active against human, group IB, pancreatic sPLA2 and was inactive against cytosolic PLA2 and the constitutive and inducible forms of cyclooxygenase.Human sPLA2-induced release of thromboxane A2 (TXA2) from isolated guinea pig lung bronchoalveolar lavage cells was inhibited by Varespladib with an IC50 of 0.79 nM. Therefore£¬the use of Varespladib have a beneficial effect in preventing various inflammatory disease states.

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