Product Information
C10560  Cyclopamine(11-Deoxyjervine)
Synonyms:11-deoxojervine
CAS No.:4449-51-8
Molecular Formula:C27H41NO2
Molecular Weight:411.62
Solubility:DMSO
Appearance:White crystalline solid
Purity:>99%
Pakage:500mg,1g,2g,5g
Storage:Desiccate at RT
Cyclopamine(11-Deoxyjervine)   Introduction:
Chemical Name: 11-Deoxojervine; (3b,23b)-17,23-Epoxy-11-deoxoveratraman-3-ol
Biological Activity:

Cyclopamine is a naturally occuring steroidal alkaloid that causes cyclopia by blocking sonic hedgehog signaling. It specifically inhibits the hedgehog (Hh) pathway by interaction with the Hh signaling protein smoothened. Cyclopamine blocks the oncogenic effects of mutations of Ptch in fibroblasts and inhibits the growth of cells lacking Ptch function. It arrested cell cycle at G0/G1 and induced apoptosis in several small-cell lung cancer cell lines at 5 µM. Cyclopamine also induces expression of the transcription factor pdx-1, which stimulates insulin secretion in differentiation protocols for mouse embryonic stem cells.

Related Article:
   Copyright© 2003-2018  Chembest Research Laboratories Limited All rights reserved. 沪ICP备11035973号
    Tel :+86-21-20908456    Fax:+86-21-58180499-808    Address:No.3377 Kangxin Road, Pudong New District,Shanghai,China    PostCode:201318