Product Information
C14205  TAK-242(Resatorvid)
CAS No.:243984-11-4
Molecular Formula:C15H17ClFNO4S
Molecular Weight:361.82
Appearance:Light yellow oil
Purity:>98% ee
Storage:at -20℃ 2 years
TAK-242(Resatorvid)   Introduction:
Chemical Name: (6R)-6-[[(2-Chloro-4-fluorophenyl)amino]sulfonyl]-1-cyclohexene-1-carboxylic acid ethyl ester
Biological Activity:
TAK-242 (resatorvid), a small-molecule-specific inhibitor of Toll-like receptor (TLR) 4 signaling, inhibits the production of lipopolysaccharide-induced inflammatory mediators by binding to the intracellular domain of TLR4. Cys747 in TLR4 has been identified previously as the binding site of TAK-242. However, the mechanism by which TAK-242 inhibits TLR4 signaling after binding to TLR4 remains unknown. The present study demonstrated, using coimmunoprecipitation, that TAK-242 interferes with protein-protein interactions between TLR4 and its adaptor molecules.

Related Article:
   Copyright© 2003-2020  Chembest Research Laboratories Limited All rights reserved. 沪ICP备11035973号
    Tel :+86-21-20908456    Fax:+86-21-58180499-808    Address:No.3377 Kangxin Road, Pudong New District,Shanghai,China    PostCode:201318