Product Information
C14314  PSC 833(Valspodar)
Synonyms:SDZ-PSC-833,Amdray
CAS No.:121584-18-7
Molecular Formula:C63H111N11O12
Molecular Weight:1214.62
Solubility:Soluble to 4 mM in DMSO
Appearance:White solid
Purity:>98%
Pakage:50mg,100mg
Storage:Store at -20°C
PSC 833(Valspodar)   Introduction:
Chemical Name: 6-[(2S,4R,6E)-4-Methyl-2-(methylamino)-3-oxo-6-octenoic acid]-7-L-valine-cyclosporin A; Cyclo[[(2S,4R,6E)-4-methyl-2-(methylamino)-3-oxo-6-octenoyl]-L-valyl-N-methylglycyl-N-methyl-L-leucyl-L-valyl-N-methyl-L-leucyl-L-alanyl-D-alanyl-N-methyl-L-leucyl-N-m
Biological Activity:
P-glycoprotein (P-gp) modulator; inhibits P-gp-mediated multidrug-resistance (MDR). Reverses resistance to several cytotoxic drugs including mitoxantrone and doxorubicin (resistance factors are 2.0 and 6.5 respectively) in human MDR cancer cell lines. Non-immunosuppressive analog of cyclosporin A.

Related Article:
Related Products:
   Copyright© 2003-2018  Chembest Research Laboratories Limited All rights reserved. 沪ICP备11035973号
    Tel :+86-21-20908456    Fax:+86-21-58180499-808    Address:No.3377 Kangxin Road, Pudong New District,Shanghai,China    PostCode:201318