Vandetanib(AZD6474)

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Pharmacology: Transporters; Nuclear Receptors; Ion Channels; 7-TM Receptors; Aurora Kinase Inhibitors; Activators; Cell Cycle/Checkpoint; CETP inhibitor; PI3K/Akt/mTOR; Angiogenesis/Tyrosine Kinase; HDAC; Cytochrome P450; Apoptosis; Proteases/HSP90/HSP70; Wnt/Hedgehog/Notch; Other Pharmacology

Research Area: Immunology; Infection; Cardiovascular Disease; Antivirals; Cancer

Product Type: Peptides; Natural Compounds

Product Information

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C14316 Vandetanib(AZD6474)

Synonyms：AZD6474,Zactima

CAS No.：443913-73-3

Molecular Formula：C22H24BrFN4O2

Molecular Weight：475.35

Solubility：DMSO

Appearance：White powder

Purity：>99%

Pakage：500mg,1g,2g,5g

Storage：at -20℃

Vandetanib(AZD6474) Introduction：

Chemical Name: 4-(4-Bromo-2-fluoroanilino)-6-methoxy-7-[(1-methylpiperidin-4-yl)methoxy]quinazoline
Biological Activity:
Vandetanib (Zactima) is a VEGFR and EGFR antagonist and a tyrosine kinase inhibitor with IC50 of 60, 90, 40 nM for HUVEC proliferation, PC-9 cells and tyrosine kinase activity, respectively. In vitro, two cell lines (OZ and HuCCT1), both of which harboured KRAS mutation, were refractory to vandetanib, one cell line (TGBC24TKB) was somewhat resistant, and another cell line (TKKK) was sensitive. The most sensitive cell line (TKKK) had EGFR amplification. Vandetanib (25 mg /kg/ day) significantly prolonged the time to metastasis in an intravenous model of TKKK metastasis.