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C13619  Entinostat(MS-275)
Synonyms:MS-275,SNDX-275
CAS No.:209783-80-2
Molecular Formula:C21H20N4O3
Molecular Weight:376.41
Solubility:Soluble in DMSO at 25 mg/mL with slight warming; very poorly soluble in ethanol&water;
Appearance:Off-white powder
Purity:>99%
Pakage:500mg,1g,2g,5g
Storage:at -20℃ 2 years
Entinostat(MS-275)   Introduction:
Biological Activity:
MS-275 (Entinostat, SNDX-275, MS-27-275) is a potent HDAC inhibitor with IC50 of 0.3 and 8µM for HDAC1 and HDAC3, respectively. MS-275 (Entinostat, SNDX-275, MS-27-275) is synthetic benzamide derivative with potential antineoplastic activity. MS-275 (Entinostat, SNDX-275, MS-27-275) has no inhibitory activity towards HDAC8 (IC50>100 µM). MS-275 (Entinostat, SNDX-275, MS-27-275) appears to exert dose-dependent effects in human leukemia cells at low concentrations in human prostate cancer cell lines. MS-275 (Entinostat, SNDX-275, MS-27-275) exerted growth arrest in PC-3 and LNCaP cells, and induced cell death in DU-145 cells.

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