Product Information
C14160  Semagacestat (LY450139)
CAS No.:425386-60-3
Molecular Formula:C19H27N3O4
Molecular Weight:361.44
Appearance:White powder
Storage:at -20℃ 2 years
Semagacestat (LY450139)   Introduction:
Biological Activity:
Semagacestat (LY450139) is a γ-secretase blocker with an IC50 of 15 nM.β-amyloid is a peptide of 39 to 43 amino acids. The isoforms with 40 and 42 amino acids (Aβ40/42) are the main constituents of amyloid plaques in the brains of Alzheimer’s disease patients. β-amyloid is formed by proteolysis of APP. Research on laboratory rats suggest that the soluble form of this peptide is a causative agent in the development of Alzheimer’s. Semagacestat blocks the enzyme γ-secretase, which (along with β-secretase) is responsible for APP proteolysis.

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