Product Information
C14043  PP 121
Synonyms:PP 121
CAS No.:1092788-83-4
Molecular Formula:C17H17N7
Molecular Weight:319.36
Solubility:Soluble in DMSO and ethanol
Appearance:
Purity:>99%
Pakage:500mg,1g,2g,5g
Storage:Store at +4°C
PP 121   Introduction:
Chemical Name: 1-Cyclopentyl-3-(1H-pyrrolo[2,3-b]pyridin-5-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine

Biological Activity:

Dual inhibitor of receptor tyrosine kinases (RTKs) (IC50 < 0.02 μM for Abl, Src, VEGFR-2 and PDGFR) and PI 3-K family kinases (IC50 < 0.06 μM for p110α, DNA-PK and mTOR). Exhibits no significant effect on receptor serine/threonine kinases (RSTKs). Blocks the proliferation of tumor cells by direct inhibition of PI 3-K, mTOR, Src and the VEGF receptor.


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